Living out in a rural area as we do, much of our driving is on back county roads. MM and I have each had our fair share of close calls with these large rodent wannabes. My scariest encounter occurred in the dark on my way home from work one day.
I didn't see it until the last moment, but there was a deer standing in the middle of the road, right on the centerline, facing the way I was driving. I didn't see it until I was right on top of it, and I swear to this day that my sideview mirror clipped it on the rearend. Had it been standing about a foot over to the right, I would have been chewing on rump roast after it smashed right through my windshield.
They're worse than squirrels. At least a squirrel is going to lose everytime, that's if you just drive right over it and not swerve. A deer though, you better try to avoid them at all cost.